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ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma
https://doi.org/10.15022/00003468
https://doi.org/10.15022/000034686d872eba-fdbe-4039-aaba-8085ce961a96
名前 / ファイル | ライセンス | アクション |
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kiyoum-33-2-061to069 (868.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-11-24 | |||||
タイトル | ||||||
タイトル | ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15022/00003468 | |||||
ID登録タイプ | JaLC | |||||
著者 |
柴田, 健一
× 柴田, 健一× 鈴木, 明彦× 渡邊, 利広× 高須, 直樹× 平井, 一郎× 木村, 理 |
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著者別名 | ||||||
姓名 | Shibata, Kenichi | |||||
著者別名 | ||||||
姓名 | Suzuki, Akihiko | |||||
著者別名 | ||||||
姓名 | Watanabe, Toshihiro | |||||
著者別名 | ||||||
姓名 | Takasu, Naoki | |||||
著者別名 | ||||||
姓名 | Hirai, Ichiro | |||||
著者別名 | ||||||
姓名 | Kimura, Wataru | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background: Epithelial-Mesenchymal Transition (EMT) plays an important role in cancer progression and metastasis. We investigated the expression of two EMT-related molecules, ZEB-1 and E-cadherin, in invasive ductal breast carcinoma and evaluated their association with clinicopathological parameters and recurrence-free survival. Methods: We evaluated the expression of ZEB-1 and E-cadherin in 116 patients of Stage I, II, and III primary invasive ductal breast carcinoma (mean age, 58.5 years, male: female = 0:116) using immunohistochemistry. Results: Of the 116 patients, 51 (44%) had Stage I, 58 (50%) had Stage II, and 7 (6%) had Stage III tumors. Thirty seven patients (32%) had lymph node metastasis. One hundred and one patients (87%) had ER positive tumors, and 20 patients (17%) had HER2 positive tumors. Positive ZEB-1 expression was observed in the tumors of 66 patients (57%), but it was not significantly associated with clinicopathological parameters. Reduced E-cadherin expression was observed in the tumors of 34 patients (29%). It was significantly associated with negative estrogen receptor expression. Patients with a positive ZEB-1 and / or reduced E-cadherin had a poorer outcome than the other patients in terms of recurrence-free survival. Conclusion: ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma. |
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書誌情報 |
山形大学紀要. 医学 : 山形医学 = Bulletin of the Yamagata University. Medical science : Yamagata medical journal 巻 33, 号 2, p. 61-69, 発行日 2015-08-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0288-030X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00067279 | |||||
その他の言語のタイトル | ||||||
その他のタイトル | ZEB-1およびE-cadherin発現は浸潤性乳管癌の再発予測因子となり得る | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma | |||||
出版者 | ||||||
出版者 | 山形大学 | |||||
出版者(ヨミ) | ||||||
ヤマガタ ダイガク | ||||||
別言語の出版者 | ||||||
Yamagata University | ||||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
紀要論文 | ||||||
資源タイプ・NII | ||||||
Departmental Bulletin Paper | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
2 |