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Genotoxicity of occupational exposure of anesthesiologists to sevoflurane : The relationship between DNA damage and the work environment
https://doi.org/10.15022/00004069
https://doi.org/10.15022/00004069fb9f28b0-3470-4774-8939-e76082653e1a
名前 / ファイル | ライセンス | アクション |
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kiyoum-34-2-085to091 (124.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-09-01 | |||||
タイトル | ||||||
タイトル | Genotoxicity of occupational exposure of anesthesiologists to sevoflurane : The relationship between DNA damage and the work environment | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.15022/00004069 | |||||
ID登録タイプ | JaLC | |||||
著者 |
大瀧, 恵
× 大瀧, 恵× 川前, 金幸× 石川, 恵生× 小田, 真也 |
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著者(ヨミ) | ||||||
姓名 | オオタキ, ケイ | |||||
著者(ヨミ) | ||||||
姓名 | カワマエ, カネユキ | |||||
著者(ヨミ) | ||||||
姓名 | イシカワ, シゲオ | |||||
著者(ヨミ) | ||||||
姓名 | オダ, シンヤ | |||||
著者別名 | ||||||
姓名 | Otaki, Kei | |||||
著者別名 | ||||||
姓名 | Kawamae, Kaneyuki | |||||
著者別名 | ||||||
姓名 | Ishikawa, Shigeo | |||||
著者別名 | ||||||
姓名 | Oda, Shinya | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background: Inhalation anesthetics are often used for general anesthesia. However, several studies have reported that occupational exposure to inhalation anesthetics induces DNA damage and that sevoflurane anesthesia causes reversible genotoxic effects in patients. Our aim was to investigate the genotoxic effects in anesthesiologists of occupational exposure to sevoflurane, and to reveal the relevance of DNA damage and the work environment of anesthesiologists. Methods: Alkaline comet assay of the peripheral blood lymphocytes of 53 anesthesiologists (exposed group) and 37 office workers (control group) was performed, following which 100 cells were classified into 5 classes: 0: no migration, to 4: very high migration, the distance of migration being dependent on the degree of DNA damage. The total comet score (TCS) was calculated as n1+2×n2+3×n3+4×n4. Anesthesiologists were asked about their work environment. Results and Conclusions: TCSs were no different between the exposed and control groups (7.16±7.88 vs. 7.63±6.73, p=0.82) (95%CI 3.91-10.41 vs. 4.97-10.29). There was no significant association between TCS and the frequency of usage of sevoflurane. In conclusion, our study did not reveal DNA damage with chronic occupational exposure to sevoflurane. |
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書誌情報 |
山形大学紀要. 医学 : 山形医学 en : Bulletin of the Yamagata University. Medical science : Yamagata medical journal 巻 34, 号 2, p. 85-91, 発行日 2016-08-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0288-030X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00067279 | |||||
その他の言語のタイトル | ||||||
その他のタイトル | 麻酔科医におけるセボフルラン慢性曝露による遺伝毒性影響 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | Genotoxicity of occupational exposure of anesthesiologists to sevoflurane : The relationship between DNA damage and the work environment | |||||
出版者 | ||||||
出版者 | 山形大学 | |||||
出版者(ヨミ) | ||||||
ヤマガタ ダイガク | ||||||
別言語の出版者 | ||||||
Yamagata University | ||||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
紀要論文 | ||||||
資源タイプ・NII | ||||||
Departmental Bulletin Paper | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
2 |