{"created":"2023-05-25T05:22:47.406985+00:00","id":108,"links":{},"metadata":{"_buckets":{"deposit":"a3884722-00e7-4579-a159-15852668c9d8"},"_deposit":{"created_by":3,"id":"108","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"108"},"status":"published"},"_oai":{"id":"oai:yamagata.repo.nii.ac.jp:00000108","sets":["29:31:148:149"]},"author_link":["279","280","281","278"],"item_3_alternative_title_18":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Detection of the Micrometastasis and Its Prognostic Significance in Malignant Tumors of the Hepatobilialy Systems"}]},"item_3_alternative_title_19":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"タンドウケイ アクセイ シュヨウ ニオケル リンパセツ ビショウ テンイ ノ リンショウテキ イギ リンパセツ ビショウ テンイ ノ ケンシュツ ホウホウ ノ カクリツ ト ヨゴ トノ カンレン ニツイテ"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-08-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"110","bibliographicPageStart":"89","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"山形大学紀要. 医学 : 山形医学 = Bulletin of the Yamagata University. Medical science : Yamagata medical journal"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"緒言：消化器癌におけるリンパ節転移の診断は通常最大割面のHematoxylin and Eosin(HE)染色で行われるため、最大割面にまで至らないような転移病巣をもつリンパ節はリンパ節転移陰性と診断される。しかしリンパ節全体の切片を作成することは事実上不可能であり、リンパ節転移陰性と診断されたなかには微小な転移がある程度の頻度で含まれていることを認識する必要がある。消化器癌ではリンパ節転移陽性症例は陰性症例に比較し予後不良であるが、リンパ節微小転移陽性の臨床的意義は不明である。一方、胆管系悪性腫瘍においてもリンパ節転移は重要な予後規定因子であるが、この領域での微小転移に関する報告はこれまで２ 、３の報告を見るのみである。そこで本研究では胆管系悪性腫瘍におけるリンパ節微小転移の検出頻度並びに予後との相関を検討し、その臨床的意義を明らかにすることを試みた。　方法：対象は肝門部胆管癌36例、漿膜下浸潤胆嚢癌24例、中下部胆管癌46例で、うち最大割面のHE染色でおこなわれた通常の病理組織検索で、リンパ節転移陰性と診断された症例のそれぞれ19例、15例、10例に対し連続切片の作成をおこなった。各切片レベルにつき２枚の切片を作成し、１枚をHE染色、あとの１枚を免疫組織化学染色を施行した。各切片レベルの間隔は40μm とした。１つのリンパ節につき平均17.1レベルでの観察を行った。免疫組織化学染色の１次抗体には抗サイトケラチン抗体を用いた。微小転移を来しやすい臨床病理的背景因子およびその予後を検討した。　結果：微小転移の検出率はそれぞれ31.5％、20.0％、0.0％であった。微小転移を来しやすい臨床病理的背景に特徴はなかった。微小転移を来した症例は予後不良である傾向を示した。しかし微小転移を来さなかった症例との統計的有意差は認めなかった。　結論：連続切片の作成と免疫染色によって検出された胆管系悪性腫瘍の微小転移の臨床的意義は明らかではなかったが、微小転移陽性症例は予後不良な傾向があり、今後大規模な研究が必要であると考えられた。　キーワード： 微小転移、免疫染色、連続切片、肝門部胆管癌、胆嚢癌","subitem_description_type":"Other"},{"subitem_description":"Background : Most commonly, the status of regional lymph node was examined by only one section in maximum diameter patho-logically. Therefore, the minute metastatic lesion was result in node negative. The most important disease-related prognostic factor in primary cancer of the digestive system is the status of regional lymph nodes. Recently, there are many reports about micro-metastases in various malignant tumors of the digestive systems. But it's prognostic significance remains to be clarified.　Methods : The lymph nodes obtained from 19 node-negative patients in hilar bile duct cancer, 15 node-negative patients in pT2 gallbladder cancer, and 10 node-negative patients in mid-and-lower bile duct cancer were sectioned at multi-level, and stained immuno-hisochemically for detecting micrometastases. And then the associations between micrometastases and other clinico-pathological variables andprognosis were assessed.　Results : Micrometastases were present in 6 cases (31.5%) in hilar bile duct cancer, 3 cases (20.0%) in pT2 gallbladder cancer, and no case in mid-and-lower bile duct cancer. The presence of micro-metastases was unrelated to any clinicopathological factors, and they were not independent factors stastically.　Conclusions : The presence of the micrometastases detected by serial sectioning and immunohistochemistry did not have significant prognostic value in primary cancer of the hepatobilialy system, a larger series would be found to dissolve this problem certainly.　Key words : micrometastases, serial section, immunohistchemistry, hilar bile duct carcinoma, gallbladder carcinoma","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"280","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sakurai,  Fumiaki"}]},{"nameIdentifiers":[{"nameIdentifier":"281","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kimura,  Wataru"}]}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山形大学"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00067279","subitem_source_identifier_type":"NCID"}]},"item_3_text_33":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ヤマガタ ダイガク"}]},"item_3_text_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_text_value":"Yamagata University"}]},"item_3_text_43":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_3_text_44":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper"}]},"item_3_text_45":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_3_text_46":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"櫻井,  文明"}],"nameIdentifiers":[{"nameIdentifier":"278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村,  理"}],"nameIdentifiers":[{"nameIdentifier":"279","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-08-21"}],"displaytype":"detail","filename":"kiyoum-21-2-089to110.pdf","filesize":[{"value":"5.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kiyoum-21-2-089to110.pdf","url":"https://yamagata.repo.nii.ac.jp/record/108/files/kiyoum-21-2-089to110.pdf"},"version_id":"31928844-75ba-4503-9e3d-208070665e7d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"胆道系悪性腫瘍におけるリンパ節微小転移の臨床的意義 : リンパ節微小転移の検出方法の確立と予後との関連について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胆道系悪性腫瘍におけるリンパ節微小転移の臨床的意義 : リンパ節微小転移の検出方法の確立と予後との関連について"}]},"item_type_id":"3","owner":"3","path":["149"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-10-22"},"publish_date":"2007-10-22","publish_status":"0","recid":"108","relation_version_is_last":true,"title":["胆道系悪性腫瘍におけるリンパ節微小転移の臨床的意義 : リンパ節微小転移の検出方法の確立と予後との関連について"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-25T06:28:47.376942+00:00"}