{"created":"2023-05-25T05:24:02.844301+00:00","id":1696,"links":{},"metadata":{"_buckets":{"deposit":"dce8b160-c651-47ec-b748-b22703cbd980"},"_deposit":{"created_by":3,"id":"1696","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1696"},"status":"published"},"_oai":{"id":"oai:yamagata.repo.nii.ac.jp:00001696","sets":["56:58"]},"author_link":["5739","5740"],"item_3_alternative_title_18":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Behavioral-genetic approach to impulsivity of ADHD"}]},"item_3_alternative_title_19":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ADHD ニオケル ショウドウセイ エノ コウドウ イデンテキ アプローチ"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-02-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"64(122)","bibliographicPageStart":"55(113)","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"山形大学紀要. 教育科学 = Bulletin of Yamagata University. Educational Science"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"　近年、神経心理学の立場から、注意欠陥・多動性障害（attention-deficit/hyper activity disorder: ADHD ）の本質は、衝動性（行動抑制の弱さ）にあり、注意散漫や多動は二次的に現れたものとする考え方が提唱されている。ADHD における衝動性は、将来の目標遂行のために目前の反応を抑制できない自己のコントロールの障害として観察される。その原因として、前頭葉における行動抑制機能の障害と、それに関連する実行機能（注意の統制、行為の持続、および適切な計画性など）の問題が指摘されているが、衝動性行動の原因は未だ完全には明らかにされていない。現在、ADHD の生物学的基盤を探るために、双生児研究や分子遺伝学研究などの遺伝的アプローチから障害に関連する遺伝子を探る研究が精力的に行われ、特に脳内ネットワークの情報伝達に欠かせない神経伝達修飾物質の異常が指摘されている。本論文では、ADHD の関連遺伝子を概観し、実験室で測定される実行機能を指標とした行動－遺伝的アプローチによる ADHD の衝動性メカニズムの解明への可能性についてまとめる。　Several researchers have proposed that symptoms of attention-deficit/hyper activity disorder (ADHD) arise from a primary deficit in behavioral inhibition (impulsivity) followed by inattention and hyperactivity. Impulsivity of ADHD represents a disorder of self-regulation, that is, a deficit in maintaining an appropriate short-term behavior in order to attain a later goal. It has been suggested that dysfunctions of behavioral inhibition in the prefrontal cortex and its marginal executive function (e.g., attention control, maintaining action, and planning) are causes for ADHD.　However, the underlying neural substrates are still unclear. Several studies based on genetic approaches such as twin and molecular genetic studies have sought to identify candidate genes and variants that increase susceptibility to ADHD. Dysfunction in some neurotransmitters has been postulated to cause ADHD. In this paper, we reviewed candidate genes associated with the vulnerability to developing ADHD and discuss the behavioral-genetic approach used to investigate the mechanisms of impulsivity in ADHD.","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"5740","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Omura,  Kazufumi"}]}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山形大学"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00242980","subitem_source_identifier_type":"NCID"}]},"item_3_text_33":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ヤマガタ ダイガク"}]},"item_3_text_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_text_value":"Yamagata University"}]},"item_3_text_43":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_3_text_44":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper"}]},"item_3_text_45":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_3_text_46":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大村,  一史"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-08-21"}],"displaytype":"detail","filename":"kiyoued-14-2-055to064.pdf","filesize":[{"value":"269.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kiyoued-14-2-055to064.pdf","url":"https://yamagata.repo.nii.ac.jp/record/1696/files/kiyoued-14-2-055to064.pdf"},"version_id":"32f20cce-ba36-43ee-9962-549dc33395ef"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ADHDにおける衝動性への行動 : 遺伝的アプローチ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ADHDにおける衝動性への行動 : 遺伝的アプローチ"}]},"item_type_id":"3","owner":"3","path":["58"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-08"},"publish_date":"2008-01-08","publish_status":"0","recid":"1696","relation_version_is_last":true,"title":["ADHDにおける衝動性への行動 : 遺伝的アプローチ"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-25T06:58:23.559648+00:00"}