{"created":"2024-02-13T01:27:08.686850+00:00","id":2000788,"links":{},"metadata":{"_buckets":{"deposit":"ad652f0d-c270-47a2-9e2e-45fcac10fc5d"},"_deposit":{"created_by":17,"id":"2000788","owner":"17","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"2000788"},"status":"published"},"_oai":{"id":"oai:yamagata.repo.nii.ac.jp:02000788","sets":["29:31:1706669033099:1706669223536"]},"author_link":[],"control_number":"2000788","item_3_alternative_title_18":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Continuation of chemotherapy facilitated by intensified treatment of idiopathic thrombocytopenic purpura in a patient with lung cancer: A case report","subitem_alternative_title_language":"en"}]},"item_3_alternative_title_19":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"トクハツセイ ケッショウバン ゲンショウセイ シハンビョウ ノ チリョウ キョウカ ニ ヨリ ハイガン カガクリョウホウ ノ ケイゾク ガ カノウ ニ ナッタ １レイ","subitem_alternative_title_language":"ja-Kana"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-02-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"82","bibliographicPageStart":"75","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"山形大学紀要. 医学 : 山形医学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Bulletin of the Yamagata University. Medical science : Yamagata medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"【背景】　Ⅳ期非小細胞肺癌の治療にあたっては種々の免疫チェックポイント阻害薬や分子標的治療薬が開発されているものの、急速進行例や自己免疫疾患などの合併症を有する場合に治療薬の選択に難渋する場合がある。特発性血小板減少性紫斑病による血小板減少症は細胞障害性抗癌薬使用の際の制約の一つであるが、特発性血小板減少性紫斑病の治療強化により血小板数の回復を認め、その後殺細胞性抗癌剤の投与が継続できた例を経験したため報告する。\n【臨床経過】　症例は68歳男性。特発性血小板減少性紫斑病のためプレドニゾロン５mg/日を内服していた。経過中に咳嗽、血痰が出現し、精査により肺腺癌（cT4N3M1a stageⅣA）と診断した。治療前の血小板数が4.5万/μLと低値であり、プレドニゾロン10 mg/日へ増量の上、ペメトレキセド単独での化学療法を行ったところ、血小板数8000/μLに低下した。血小板輸血を行った上でプレドニゾロン25 mg/日に増量し、エルトロンボパグ12.5 mg/日の投与を開始したところ血小板数は回復を認めた。血小板数10万/μLを安定して維持できる状態となったため、ペメトレキセドとカルボプラチンを用いての化学療法を実施可能となった。抗癌剤投与後に血小板数は減少したものの10万/μL以下に低下することはなかった。治療経過中に喀血や皮下出血といった有害事象は認めなかった。ペメトレキセドとカルボプラチンの併用療法を６コース実施し原発病変および肺門縦隔リンパ節病変の著明な縮小を認めた。\n【結論】　特発性血小板減少性紫斑病などの血球減少症を合併する患者でも、特発性血小板減少性紫斑病の治療強化により化学療法を継続できる可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"names":[{"name":"カンノ,ユウタ","nameLang":"ja-Kana"}]},{"names":[{"name":"フルヤマ,コウダイ","nameLang":"ja-Kana"}]},{"names":[{"name":"ハナワ,トシナリ","nameLang":"ja-Kana"}]},{"names":[{"name":"フクシマ,シゲユキ","nameLang":"ja"}]},{"names":[{"name":"イシバシ,ユウ","nameLang":"ja-Kana"}]},{"names":[{"name":"ヒラマ,ノリユキ","nameLang":"ja-Kana"}]},{"names":[{"name":"スズキ,イクコ","nameLang":"ja-Kana"}]},{"names":[{"name":"ナワ,サチエ","nameLang":"ja-Kana"}]},{"names":[{"name":"イノウエ,スミト","nameLang":"ja-Kana"}]},{"names":[{"name":"ワタナベ,マサフミ","nameLang":"ja-Kana"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"Yuta,Kanno","nameLang":"en"}]},{"names":[{"name":"Kodai,Furuyama","nameLang":"en"}]},{"names":[{"name":"Toshinari,Hanawa","nameLang":"en"}]},{"names":[{"name":"Shigeyuki,Fukushima","nameLang":"en"}]},{"names":[{"name":"Yu,Ishibashi","nameLang":"en"}]},{"names":[{"name":"Noriyuki,Hirama","nameLang":"en"}]},{"names":[{"name":"Ikuko,Suzuki","nameLang":"en"}]},{"names":[{"name":"Sachie,Nawa","nameLang":"en"}]},{"names":[{"name":"Sumito,Inoue","nameLang":"en"}]},{"names":[{"name":"Masafumi,Watanabe","nameLang":"en"}]}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15022/0002000788","subitem_identifier_reg_type":"JaLC"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山形大学","subitem_publisher_language":"ja"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-030X","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00067279","subitem_source_identifier_type":"NCID"}]},"item_3_text_33":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_language":"ja-Kana","subitem_text_value":"ヤマガタ ダイガク"}]},"item_3_text_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Yamagata University"}]},"item_3_text_43":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_3_text_44":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin 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purpura","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Thrombocytopenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Eltrombopag","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"特発性血小板減少性紫斑病の治療強化により 肺癌化学療法の継続が可能になった１例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"特発性血小板減少性紫斑病の治療強化により 肺癌化学療法の継続が可能になった１例","subitem_title_language":"ja"}]},"item_type_id":"3","owner":"17","path":["1706669223536"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-21"},"publish_date":"2024-02-21","publish_status":"0","recid":"2000788","relation_version_is_last":true,"title":["特発性血小板減少性紫斑病の治療強化により 肺癌化学療法の継続が可能になった１例"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2024-04-11T03:59:33.801086+00:00"}