{"created":"2025-02-03T00:20:33.762594+00:00","id":2001364,"links":{},"metadata":{"_buckets":{"deposit":"03d1374e-7dad-4044-85ef-67f8727a2209"},"_deposit":{"created_by":17,"id":"2001364","owner":"17","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"2001364"},"status":"published"},"_oai":{"id":"oai:yamagata.repo.nii.ac.jp:02001364","sets":["29:31:1738194972313:1738214144409"]},"author_link":[],"control_number":"2001364","item_3_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025-02-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"24","bibliographicPageStart":"19","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"山形大学紀要. 医学 : 山形医学","bibliographic_titleLang":"ja"},{"bibliographic_title":"Bulletin of the Yamagata University. Medical science : Yamagata medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_42":{"attribute_name":"item_3_description_42","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"【目的】本邦では2020年に、遺伝性乳癌卵巣癌と診断された乳癌既発症者に対するリスク低減卵管卵巣摘出術（Risk reducing salpingo‒oophorectomy: RRSO）が保険適用となった。当院において保険適用後に行われたRRSOの実際を明らかにすることを目的とした。\n【方法】2021年４月から2024年３月の３年間に当院でRRSOを行った症例の診療録から後方視的に情報を収集した。各症例の病歴、家族歴、既往歴、手術内容、遺伝子変異、病理学的所見などについて検討した。\n【結果】対象症例は18例で、年齢の中央値は47.5歳（41-64）であった。18例のうち17例は乳癌の既往があったが、１例のみ乳癌の既往がないため自費でRRSOを行った。全ての症例でBRCA1/2の病的バリアントが同定されており、BRCA1の病的バリアントを認めたのが10例、BRCA2の病的バリアントが８例であった。乳癌の既往のあった17例のうち、BRCA1病的バリアント保持者10例では乳癌の初回手術時の年齢が中央値40歳（34-51）で、RRSOまで中央値で７年（0-19）が経過していた。一方BRCA2病的バリアント保持者７例では乳癌の初回手術時の年齢が中央値46歳（41-57）で、RRSOまで中央値２年（0-7）であった。BRCA2病的バリアント保持者のうち１例は乳癌の手術とRRSOを同時に行っていた。乳癌の既往のある17例のうち４例では乳癌の初回手術の前にBRCA遺伝学的検査が行われており、乳癌の治療と並行してRRSOが検討されていた。\n【結論】BRCA1病的バリアント保持者では、BRCA2病的バリアント保持者と比較して乳癌の初回手術からRRSOまでの期間が長い症例が多かったが、BRCA1病的バリアント保持者の方が若年で乳癌に罹患しやすいことを反映していると考えられた。乳癌の初回手術前からBRCA遺伝学的検査が行われている症例が複数あり、より早期からの遺伝カウンセリングの重要性が増している。","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"names":[{"name":"ノリカズ,ワタナベ","nameLang":"ja-Kana"}]},{"names":[{"name":"リサコ,ヤマグチ","nameLang":"ja-Kana"}]},{"names":[{"name":"フミヒロ,ナカムラ","nameLang":"ja-Kana"}]},{"names":[{"name":"ショウタ,ホリカワ","nameLang":"ja-Kana"}]},{"names":[{"name":"トモミチ,イトウ","nameLang":"ja-Kana"}]},{"names":[{"name":"ヨウスケ,オクイ","nameLang":"ja-Kana"}]},{"names":[{"name":"ミカ,フカセ","nameLang":"ja-Kana"}]},{"names":[{"name":"ジュン,マツカワ","nameLang":"ja-Kana"}]},{"names":[{"name":"ヒロツグ,サカキ","nameLang":"ja-Kana"}]},{"names":[{"name":"マナブ,セイノ","nameLang":"ja-Kana"}]},{"names":[{"name":"ケイコ,ヤマノウチ","nameLang":"ja-Kana"}]},{"names":[{"name":"ユウキ,ホシ","nameLang":"ja-Kana"}]},{"names":[{"name":"ツヨシ,オオタ","nameLang":"ja-Kana"}]},{"names":[{"name":"マサアキ,カワイ","nameLang":"ja-Kana"}]},{"names":[{"name":"サトル,ナガセ","nameLang":"ja-Kana"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"names":[{"name":"Norikazu,Watanabe","nameLang":"en"}]},{"names":[{"name":"Risako,Yamaguchi","nameLang":"en"}]},{"names":[{"name":"Fumihiro,Nakamura,","nameLang":"en"}]},{"names":[{"name":"Shota,Horikawa","nameLang":"en"}]},{"names":[{"name":"Tomomichi,Ito","nameLang":"en"}]},{"names":[{"name":"Yosuke,Okui","nameLang":"en"}]},{"names":[{"name":"Mika,Fukase","nameLang":"en"}]},{"names":[{"name":"Jun,Matsukawa","nameLang":"en"}]},{"names":[{"name":"Hirotsugu,Sakaki","nameLang":"en"}]},{"names":[{"name":"Manabu,Seino","nameLang":"en"}]},{"names":[{"name":"Keiko,Yamanouchi","nameLang":"en"}]},{"names":[{"name":"Yuki,Hoshi","nameLang":"en"}]},{"names":[{"name":"Tsuyoshi,Ohta","nameLang":"en"}]},{"names":[{"name":"Masaaki,Kawai","nameLang":"en"}]},{"names":[{"name":"Satoru,Nagase","nameLang":"en"}]}]},"item_3_identifier_registration":{"attribute_name":"identifier_registration","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15022/0002001364","subitem_identifier_reg_type":"JaLC"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山形大学","subitem_publisher_language":"ja"}]},"item_3_source_id_7":{"attribute_name":"item_3_source_id_7","attribute_value_mlt":[{"subitem_source_identifier":"0288-030X","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_9":{"attribute_name":"item_3_source_id_9","attribute_value_mlt":[{"subitem_source_identifier":"AN00067279","subitem_source_identifier_type":"NCID"}]},"item_3_text_33":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_language":"ja-Kana","subitem_text_value":"ヤマガタ ダイガク"}]},"item_3_text_34":{"attribute_name":"item_3_text_34","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Yamagata University"}]},"item_3_text_43":{"attribute_name":"item_3_text_43","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_3_text_44":{"attribute_name":"item_3_text_44","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin 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salpingo-oophorectomy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Genetic counseling","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"遺伝性乳癌卵巣癌に対するリスク低減卵管卵巣摘出術の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"遺伝性乳癌卵巣癌に対するリスク低減卵管卵巣摘出術の検討","subitem_title_language":"ja"},{"subitem_title":"イデンセイ ニュウガン ランソウガン ニタイスル リスク ケイゲン ランカン ランソウ テキシュツジュツ ノ ケントウ","subitem_title_language":"ja-Kana"},{"subitem_title":"Three-year report of risk-reducing salpingo-oophorectomy performed at a single 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