{"created":"2023-05-25T05:22:53.173195+00:00","id":205,"links":{},"metadata":{"_buckets":{"deposit":"607644e6-7104-4141-a644-08145fdde1e5"},"_deposit":{"created_by":3,"id":"205","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"205"},"status":"published"},"_oai":{"id":"oai:yamagata.repo.nii.ac.jp:00000205","sets":["29:31:130:131"]},"author_link":["797","794","796","795","793","798"],"item_3_alternative_title_18":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"デキストラン硫酸誘発マウス大腸炎に対するリポソーム封入NF-κBデコイオリゴデオキシリボ核酸の検討"}]},"item_3_alternative_title_19":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"デキストラン リュウサン ユウハツ マウス ダイチョウエン ニ タイスル リポソーム フウニュウ NF-κB デコイ オリゴ デオキシリボ カクサン ノ ケントウ"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-08-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"117","bibliographicPageStart":"109","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"山形大学紀要. 医学 : 山形医学 = Bulletin of the Yamagata University. Medical science : Yamagata medical journal"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"BACKGROUNDS/AIMS: Double strand nuclear factor-κB decoy oligodeoxynucleotide (NF-κB-Decoy) had been investigated as a potential therapeutic approach in ulcerative colitis. Here we confirm that NF-κB-Decoy inhibits inflammatory cytokines production in vitro, and report initial studies of the use of liposome-conjugated NF-κB-Decoy to treat dextran sodium sulphate (DSS)-induced colitis. METHODS: (1) Peripheral blood samples or cultured Colo 205, colon cancer cells were pretreated with NF-κB-Decoy and stimulated with lipopolysaccharide. (2) Eight-weeks-old female BALB/C mice were fed 4% DSS in drinking water for 7 days. Intra-colonic administration of liposomeconjugated NF-κB-Decoy started at the same time as DSS treatment, and continued for 14 days. RESULTS: (1) In the peripheral blood, NF-κB-Decoy significantly inhibited interleukin (IL)-6 production (Tukey test, p<0.05). In the cultured cells, NF-κB-Decoy significantly reduced IL-8 production (t-test, p<0.01). (2) During administration of DSS, mortality rate between NF-κB-Decoy treated and control mice (72.4% and 57.6% respectively) was not significantly different, and body weight loss and histopathological dameges were similar in both groups. But, after discontinuation of DSS, NF-κB-Decoytreated mice regained body weight significantly earlier than did control mice. CONCLUSIONS: NF-κB-Decoy actually inhibited IL-6 and IL-8 production in vitro. Although liposome-conjugated NF-κB-Decoy could not show amelioration in DSS mice model, NF-κB-Decoy treated mice showed earlier regain of body weight.","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"796","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Suzuki,  Yasukuni"}]},{"nameIdentifiers":[{"nameIdentifier":"797","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takeda,  Hiroaki"}]},{"nameIdentifiers":[{"nameIdentifier":"798","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kawata,  Sumio"}]}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山形大学"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00067279","subitem_source_identifier_type":"NCID"}]},"item_3_text_33":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ヤマガタ ダイガク"}]},"item_3_text_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_text_value":"Yamagata University"}]},"item_3_text_43":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_3_text_44":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper"}]},"item_3_text_45":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_3_text_46":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木,  康之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"武田,  弘明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河田,  純男"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2015-08-21"}],"displaytype":"detail","filename":"kiyoum-27-2-109to117.pdf","filesize":[{"value":"142.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kiyoum-27-2-109to117.pdf","url":"https://yamagata.repo.nii.ac.jp/record/205/files/kiyoum-27-2-109to117.pdf"},"version_id":"91434763-2ec8-48b5-9a86-d92a402c41b0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Investigation of liposome-conjugated Nuclear Factor-κB Decoy Oligodeoxynucleotide in a Mouse Model of Dextran Sodium Sulphate-induced Colitis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Investigation of liposome-conjugated Nuclear Factor-κB Decoy Oligodeoxynucleotide in a Mouse Model of Dextran Sodium Sulphate-induced Colitis"}]},"item_type_id":"3","owner":"3","path":["131"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-10-06"},"publish_date":"2011-10-06","publish_status":"0","recid":"205","relation_version_is_last":true,"title":["Investigation of liposome-conjugated Nuclear Factor-κB Decoy Oligodeoxynucleotide in a Mouse Model of Dextran Sodium Sulphate-induced Colitis"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-25T06:24:01.697095+00:00"}