{"created":"2023-05-25T05:25:13.341868+00:00","id":3481,"links":{},"metadata":{"_buckets":{"deposit":"942a13cd-7a03-4c37-bf2e-f249b1b459fd"},"_deposit":{"created_by":3,"id":"3481","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3481"},"status":"published"},"_oai":{"id":"oai:yamagata.repo.nii.ac.jp:00003481","sets":["29:31:109:110"]},"author_link":["11054","11052","11049","11058","11051","11048","11057","11059","11050","11055","11056","11053"],"item_3_alternative_title_18":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ZEB-1およびE-cadherin発現は浸潤性乳管癌の再発予測因子となり得る"}]},"item_3_alternative_title_19":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"69","bibliographicPageStart":"61","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"山形大学紀要. 医学 : 山形医学 = Bulletin of the Yamagata University. Medical science : Yamagata medical journal"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Background: Epithelial-Mesenchymal Transition (EMT) plays an important role in cancer progression and metastasis. We investigated the expression of two EMT-related molecules, ZEB-1 and E-cadherin, in invasive ductal breast carcinoma and evaluated their association with clinicopathological parameters and recurrence-free survival.\nMethods: We evaluated the expression of ZEB-1 and E-cadherin in 116 patients of Stage I, II, and III primary invasive ductal breast carcinoma (mean age, 58.5 years, male: female = 0:116) using immunohistochemistry.\nResults: Of the 116 patients, 51 (44%) had Stage I, 58 (50%) had Stage II,　and 7 (6%) had Stage III tumors. Thirty seven patients (32%) had lymph node metastasis. One hundred and one patients (87%) had ER positive tumors, and 20 patients (17%) had HER2 positive tumors. Positive ZEB-1 expression was observed in the tumors of 66 patients (57%), but it was not significantly associated with clinicopathological parameters. Reduced E-cadherin expression was observed in the tumors of 34 patients (29%). It was significantly associated with negative estrogen receptor expression. Patients with a positive ZEB-1 and / or reduced E-cadherin had a poorer outcome than the other patients in terms of recurrence-free survival.\nConclusion: ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma.","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11054","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Shibata,  Kenichi"}]},{"nameIdentifiers":[{"nameIdentifier":"11055","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Suzuki,  Akihiko"}]},{"nameIdentifiers":[{"nameIdentifier":"11056","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Watanabe,  Toshihiro"}]},{"nameIdentifiers":[{"nameIdentifier":"11057","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takasu,  Naoki"}]},{"nameIdentifiers":[{"nameIdentifier":"11058","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hirai,   Ichiro"}]},{"nameIdentifiers":[{"nameIdentifier":"11059","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kimura,  Wataru"}]}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15022/00003468","subitem_identifier_reg_type":"JaLC"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山形大学"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-030X","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00067279","subitem_source_identifier_type":"NCID"}]},"item_3_text_33":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ヤマガタ ダイガク"}]},"item_3_text_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_text_value":"Yamagata University"}]},"item_3_text_43":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_3_text_44":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper"}]},"item_3_text_45":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_3_text_46":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柴田,  健一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鈴木,  明彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"渡邊,  利広"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高須,  直樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平井,  一郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"木村,  理"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-04-18"}],"displaytype":"detail","filename":"kiyoum-33-2-061to069.pdf","filesize":[{"value":"868.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kiyoum-33-2-061to069","url":"https://yamagata.repo.nii.ac.jp/record/3481/files/kiyoum-33-2-061to069.pdf"},"version_id":"4375dabb-e0a4-4097-8721-a90d5d572b41"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma"}]},"item_type_id":"3","owner":"3","path":["110"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-24"},"publish_date":"2015-11-24","publish_status":"0","recid":"3481","relation_version_is_last":true,"title":["ZEB-1 and E-cadherin expression may predict recurrence-free survival in patients with invasive ductal breast carcinoma"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-25T06:31:30.362547+00:00"}