@article{oai:yamagata.repo.nii.ac.jp:00004825,
 author = {Suzuki, Yu and Seto, Junji and Shimotai, Yoshitaka and Itagaki, Tsutomu and Katsushima, Yuriko and Katsushima, Fumio and Ikeda, Tatsuya and Mizuta, Katsumi and Hongo, Seiji and Matsuzaki, Yoko},
 issue = {1},
 journal = {山形大学紀要. 医学 : 山形医学, Bulletin of the Yamagata University. Medical science : Yamagata medical journal},
 month = {Feb},
 note = {論文(Article), Background: We previously revealed that several multiple-locus variable-number tandem-repeat analyses（MLVA）and P1 types of Mycoplasma pneumoniae（M. pneumoniae）cocirculated between 2011 and 2013 in Yamagata, Japan. However, the regional spread of M. pneumoniae infection by genotype is not reported yet. It remains unclear whether there is a difference in the spread of macrolide-resistant M. pneumoniae among genotypes. 
Methods: Genotypes were labeled according to 4-locus（Mpn 13, 14, 15, and 16）MLVA and P1 types. A total of 208 strains belonging to three major genotypes, i.e., type 4-5-7-2, 1; 4-5-7-3, 1; and 3-5-6-2, 2c, were analyzed by combining with the information of macrolide resistance-associated mutation and the patients’ information including residence. 
Results and Discussion: The three genotypes were widely distributed over more than four cities and towns in Yamagata Prefecture, cocirculating between late 2011 and early 2013, and there was little difference in the duration of their epidemics. Timing of macrolide-resistant strain appearance during the epidemic period differed between type 4-5-7-2, 1 and type 4-5-7-3, 1, and it did not appear throughout type 3-5-6-2, 2c epidemic. These genotypic differences can account for the variation in the prevalence of macrolide resistance-associated mutations in each of the studied areas.},
 pages = {19--24},
 title = {Regional spread of three distinct genotypes of Mycoplasma pneumoniae and different timing of macrolide-resistant strain appearance among genotypes between 2011 and 2013 in Yamagata, Japan},
 volume = {38},
 year = {2020}
}