{"created":"2023-05-25T05:26:13.701127+00:00","id":4958,"links":{},"metadata":{"_buckets":{"deposit":"ca7537d3-b9bf-4746-8f92-865ce892bb11"},"_deposit":{"created_by":17,"id":"4958","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"4958"},"status":"published"},"_oai":{"id":"oai:yamagata.repo.nii.ac.jp:00004958","sets":["29:31:188:189"]},"author_link":["15172","15180","15171","15179","15181","15174","15187","15175","15183","15184","15173","15176","15177","15185","15170","15182","15186","15178"],"item_3_alternative_title_18":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"インターロイキン-21はCD8陽性エフェクター記憶Ｔ細胞を介してリステリア菌の再感染を軽減する"}]},"item_3_alternative_title_19":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"インターロイキンｰ２１ハ CD８ ヨウセイエフェクターキオク Tサイボウ ヲ カイシテ リステリアキン ノ サイカンセン ヲ ケイゲン スル"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-02-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"51","bibliographicPageStart":"45","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"山形大学紀要. 医学 : 山形医学 "},{"bibliographic_title":"Bulletin of the Yamagata University. Medical science : Yamagata medical journal ","bibliographic_titleLang":"en"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article) ","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Background: Purpose: Interleukin-21 （IL-21） is mainly produced from CD4＋ T cells and has broad impact on immune responses. IL-21 isoform is a splicing variant of IL-21 and is functionally similar to conventional IL-21. We established IL-21 isoform transgenic mice （IL-21isoTg）, which constitutively express IL-21 isoform specifically in T cells. IL-21isoTg possess high amount of CD8＋ T cells in normal physiological condition. The purpose of this study is to determine whether CD8＋ T cells in the IL-21isoTg work against intracellular bacteria infection.Methods: Wild type mice （WT） and IL-21isoTg are orally inoculated Listeria monocytogenes （L. monocytogenes） on day 0, and 15 days after primary infection. Bacterial load in each organs, and T cell responses are analyzed.Results: IL-21isoTg and WT had similar bacterial load after primary infection. On the other hand, after secondary infection, IL-21isoTg exhibited reduced bacterial load in some organs and showed higher levels of CD8＋ effector memory T （TEM） cells tnWT.Conclusion: IL-21-induced CD8＋ TEM cells might eventually reduce the bacterial load after secondary infection. To the best of our knowledge, this is the first study to show that IL-21 is a pivotal factor involved in eliminating intracellular bacteria, probably through CD8＋ TEM cells.","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"15176","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Md. Yeashin , Gazi"}]},{"nameIdentifiers":[{"nameIdentifier":"15177","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タケダ, ユウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"15178","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナラ, ヒデトシ"}]},{"nameIdentifiers":[{"nameIdentifier":"15179","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アラキ, アケミ"}]},{"nameIdentifiers":[{"nameIdentifier":"15180","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ネモト, ノブヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"15181","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アサオ, ヒロノブ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"15182","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Md. Yeashin, Gazi"}]},{"nameIdentifiers":[{"nameIdentifier":"15183","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takeda, Yuji"}]},{"nameIdentifiers":[{"nameIdentifier":"15184","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nara, Hidetoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"15185","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Araki, Akemi"}]},{"nameIdentifiers":[{"nameIdentifier":"15186","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nemoto, Nobuhito"}]},{"nameIdentifiers":[{"nameIdentifier":"15187","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Asao, Hironobu"}]}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15022/00004901","subitem_identifier_reg_type":"JaLC"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山形大学 "}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-030X","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00067279","subitem_source_identifier_type":"NCID"}]},"item_3_text_33":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ヤマガタ ダイガク "}]},"item_3_text_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_text_value":"Yamagata University"}]},"item_3_text_43":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_3_text_44":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper "}]},"item_3_text_45":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_3_text_46":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Md. Yeashin , Gazi"}],"nameIdentifiers":[{"nameIdentifier":"15170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武田, 裕司"}],"nameIdentifiers":[{"nameIdentifier":"15171","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奈良, 英利"}],"nameIdentifiers":[{"nameIdentifier":"15172","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒木, 明美"}],"nameIdentifiers":[{"nameIdentifier":"15173","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根本, 信仁"}],"nameIdentifiers":[{"nameIdentifier":"15174","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"浅尾, 裕信"}],"nameIdentifiers":[{"nameIdentifier":"15175","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-02-19"}],"displaytype":"detail","filename":"kiyoum-39-1-45to51.pdf","filesize":[{"value":"267.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kiyoum-39-1-45to51","url":"https://yamagata.repo.nii.ac.jp/record/4958/files/kiyoum-39-1-45to51.pdf"},"version_id":"d033ecf6-2216-4b9e-8498-89a41a603668"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"challenge infectione","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ffector memory T cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-21, IL-21 isoform","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Listeria monocytogenes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Interleukin-21 reduces Listeria monocytogenes secondary infection via CD8＋ effector memory T cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Interleukin-21 reduces Listeria monocytogenes secondary infection via CD8＋ effector memory T cells","subitem_title_language":"en"}]},"item_type_id":"3","owner":"17","path":["189"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-02-19"},"publish_date":"2021-02-19","publish_status":"0","recid":"4958","relation_version_is_last":true,"title":["Interleukin-21 reduces Listeria monocytogenes secondary infection via CD8＋ effector memory T cells"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-05-25T06:18:16.711151+00:00"}