{"created":"2023-05-25T05:26:34.186413+00:00","id":5379,"links":{},"metadata":{"_buckets":{"deposit":"815bb5ba-a30f-47f4-a744-55a4d585c3a8"},"_deposit":{"created_by":17,"id":"5379","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"5379"},"status":"published"},"_oai":{"id":"oai:yamagata.repo.nii.ac.jp:00005379","sets":["29:31:355:356"]},"author_link":["16182","16187","16181","16184","16180","16188","16185","16183","16186","16189"],"item_3_alternative_title_18":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"細胞の挙動に関連する細胞シグナル伝達の５つのパターン"}]},"item_3_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-02-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"20","bibliographicPageStart":"1","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"山形大学紀要. 医学 : 山形医学"},{"bibliographic_title":"Bulletin of the Yamagata University. Medical science : Yamagata medical journal","bibliographic_titleLang":"en"}]}]},"item_3_description_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Signal transduction is thought to control flexible cellular responses by combining a specific robust response with a regulatory ability to interact with multiple signals. Previous biophysical studies have proposed that cell behavior be expressed in a multidimensional space with a basin of attractors. Alternatively, flow cytometry analysis provides mean fluorescence intensity（ MFI） and coefficient of variation （CV） in an arbitrary cell population. In terms of the biophysical concept, MFI and CV are considered to be the activation energy and cell fluctuations, respectively. In the current study, we present a new approach to understand cell signaling pathways associated with cell behavior linking the above concepts. To link the biophysical concept and flow cytometry data, we measured the phosphorylation levels of signal transducers in a cell and the fluctuation of the phosphorylation level in a population of cells. Topologically, the changes in MFI and CV were categorized into five patterns,which indicated emergent properties of cell behavior. The novel classification method is a simple and effective approach for classifying unknown network systems without using machine learning algorithms or ontology analysis","subitem_description_type":"Other"}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"16180","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takeda, Yuji"}]},{"nameIdentifiers":[{"nameIdentifier":"16181","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kawano, Kazuharu"}]},{"nameIdentifiers":[{"nameIdentifier":"16182","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ma, Rui "}]},{"nameIdentifiers":[{"nameIdentifier":"16183","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Saitoh, Shinichi"}]},{"nameIdentifiers":[{"nameIdentifier":"16184","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Asao, Hironobu "}]}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15022/00005304","subitem_identifier_reg_type":"JaLC"}]},"item_3_publisher_32":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"山形大学"}]},"item_3_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-030X","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00067279","subitem_source_identifier_type":"NCID"}]},"item_3_text_33":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ヤマガタ ダイガク"}]},"item_3_text_34":{"attribute_name":"別言語の出版者","attribute_value_mlt":[{"subitem_text_value":"Yamagata University"}]},"item_3_text_43":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"紀要論文"}]},"item_3_text_44":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Departmental Bulletin Paper"}]},"item_3_text_45":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_3_text_46":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"武田, 裕司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河野, 和晴"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"馬, 銳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"斉藤, 真一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"浅尾, 裕信"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-22"}],"displaytype":"detail","filename":"kiyoum-40-1-1to20.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kiyoum-40-1-1to20","url":"https://yamagata.repo.nii.ac.jp/record/5379/files/kiyoum-40-1-1to20.pdf"},"version_id":"a8127251-11bf-417c-b306-423e7c1e0e1f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ocell behavior","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell signaling pathway","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"emergent property","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"flow cytometry","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphorylation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Five Patterns of Cell Signaling Associated with Cell Behavior","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Five Patterns of Cell Signaling Associated with Cell Behavior"}]},"item_type_id":"3","owner":"17","path":["356"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-22"},"publish_date":"2022-02-22","publish_status":"0","recid":"5379","relation_version_is_last":true,"title":["Five Patterns of Cell Signaling Associated with Cell Behavior"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-05-25T06:04:52.487724+00:00"}