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Efficacy of Electrochemotherapy with Bleomycin to the Murine Osteosarcoma Model
https://yamagata.repo.nii.ac.jp/records/3473
https://yamagata.repo.nii.ac.jp/records/3473254d476e-3993-4acd-9f7c-db7923106915
名前 / ファイル | ライセンス | アクション |
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kiyoum-33-1-009to015.pdf (203.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-11-24 | |||||
タイトル | ||||||
タイトル | Efficacy of Electrochemotherapy with Bleomycin to the Murine Osteosarcoma Model | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
石川, 朗
× 石川, 朗× 土屋, 登嗣× 菅原, 正登× 高木, 理彰 |
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著者別名 | ||||||
姓名 | Ishikawa, Akira | |||||
著者別名 | ||||||
姓名 | Tsuchiya, Takashi | |||||
著者別名 | ||||||
姓名 | Sugawara, Masato | |||||
著者別名 | ||||||
姓名 | Takagi, Michiaki | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Background : Electrochemotherapy is an unique treatment to enhance the drug permeability of tumor cells. It is believed that osteosarcoma lacks the membrane proteins, which constitutes an obstacle in achieving drug transport for chemotherapy. We performed the electrochemotherapy with bleomycin to evaluate the efficacy of the treatment in an animal model of osteosarcoma. The tumor response, tissue concentration of bleomycin and histology were analyzed. Materials and Methods : SCID mice that had been subcutaneously implanted with osteosarcoma cells were subjected to electroporation, bleomycin, both or with no treatment as a control. Results : Cells cycle arrest and growth inhibiton were observed in the murine osteosarcoma only in the electroporation with bleomycin plus group. The tissue concentrations of bleomycin were high in the bleomycin plus group and low in the bleomycin alone group. Conclusion : The present study indicates that electrochemotherapy with bleomycin may be an effective treatment for osteosarcoma |
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書誌情報 |
山形大学紀要. 医学 : 山形医学 = Bulletin of the Yamagata University. Medical science : Yamagata medical journal 巻 33, 号 1, p. 9-15, 発行日 2015-02-15 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0288-030X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00067279 | |||||
その他の言語のタイトル | ||||||
その他のタイトル | 骨肉腫の動物モデルにBleomycinを用いたElectrochemotherapyの有効性 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | Efficacy of Electrochemotherapy with Bleomycin to the Murine Osteosarcoma Model | |||||
出版者 | ||||||
出版者 | 山形大学 | |||||
出版者(ヨミ) | ||||||
ヤマガタ ダイガク | ||||||
別言語の出版者 | ||||||
Yamagata University | ||||||
資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
紀要論文 | ||||||
資源タイプ・NII | ||||||
Departmental Bulletin Paper | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
2 |